Calcium phosphate glasses offer an exclusive combination of optical, bioresorbable, and enhanced thermo-mechanical properties, making them an attractive material for fabricating resorbable biomedical devices. In the present study, we report the in vitro dissolution test of a multimode (MM) phosphate fiber and a hollow fiber in phosphate buffered saline (PBS) solution. The power transmission change with the MM fiber's invitro dissolution is also presented. Then, using the same respective glass compositions of the MM fiber and hollow fiber, we report the realization of a novel bi-functional micro structured optical fiber with a MM core for light delivery and a microfluidic channel for drug delivery. The multistage fabrication process involves the techniques of extrusion, rod -in-tube, and stack-and-draw. The core was tested for light guidance and the channel for liquid delivery. The proposed approach illustrates the vast potentiality of phosphate glass based micro -structured fibers that could be used as a theranostic device to be implanted at specific areas inside the body without needing an explant procedure.

Towards a novel bi-functional bioresorbable micro-structured optical fiber for theranostic applications / Pandayil, Jt; Rizi, Shm; Russo, S; Boetti, Ng; Pugliese, D; Janner, D. - 12627:(2023). (Intervento presentato al convegno European Conferences on Biomedical Optics 2023 tenutosi a Munich, Germany nel 25-29 Giugno 2023) [10.1117/12.2670867].

Towards a novel bi-functional bioresorbable micro-structured optical fiber for theranostic applications

Pugliese, D;
2023

Abstract

Calcium phosphate glasses offer an exclusive combination of optical, bioresorbable, and enhanced thermo-mechanical properties, making them an attractive material for fabricating resorbable biomedical devices. In the present study, we report the in vitro dissolution test of a multimode (MM) phosphate fiber and a hollow fiber in phosphate buffered saline (PBS) solution. The power transmission change with the MM fiber's invitro dissolution is also presented. Then, using the same respective glass compositions of the MM fiber and hollow fiber, we report the realization of a novel bi-functional micro structured optical fiber with a MM core for light delivery and a microfluidic channel for drug delivery. The multistage fabrication process involves the techniques of extrusion, rod -in-tube, and stack-and-draw. The core was tested for light guidance and the channel for liquid delivery. The proposed approach illustrates the vast potentiality of phosphate glass based micro -structured fibers that could be used as a theranostic device to be implanted at specific areas inside the body without needing an explant procedure.
2023
European Conferences on Biomedical Optics 2023
25-29 Giugno 2023
Munich, Germany
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11696/78220
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