We report on the employment of a biodegradable phosphate-based optical fiber as a pH sensing probe in physiological environment. The phosphate-based optical fiber preform was fabricated by the rod-in-tube technique. The fiber biodegradability was first tested in-vitro and then its biodegradability and toxicity were tested in-vivo. Optical probes for pH sensing were prepared by the immobilization of a fluorescent dye on the fiber tip by a sol-gel method. The fluorescence response of the pH-sensor was measured as a ratio of the emission intensities at the excitation wavelengths of 405 and 450 nm.
Biomedical and sensing applications of a multi-mode biodegradable phosphate-based optical fiber / Podrazky, O.; Peterka, P.; Vytykacova, S.; Probostova, J.; Kunes, M.; Lyutakov, O.; Ceci-Ginistrelli, E.; Pugliese, D.; Boetti, N. G.; Janner, D.; Milanese, D.. - In: PROGRESS IN BIOMEDICAL OPTICS AND IMAGING. - ISSN 1605-7422. - 10488:(2018). (Intervento presentato al convegno Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018 tenutosi a usa nel 2018) [10.1117/12.2285148].
Biomedical and sensing applications of a multi-mode biodegradable phosphate-based optical fiber
Pugliese D.;
2018
Abstract
We report on the employment of a biodegradable phosphate-based optical fiber as a pH sensing probe in physiological environment. The phosphate-based optical fiber preform was fabricated by the rod-in-tube technique. The fiber biodegradability was first tested in-vitro and then its biodegradability and toxicity were tested in-vivo. Optical probes for pH sensing were prepared by the immobilization of a fluorescent dye on the fiber tip by a sol-gel method. The fluorescence response of the pH-sensor was measured as a ratio of the emission intensities at the excitation wavelengths of 405 and 450 nm.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
