In this work the preparation of tissue mimicking materials (TMMs) with independently tunable acoustic and elastic properties is reported. Although a large number of hydrogel, synthetic polymer, polysaccharides or other natural based materials have been proposed and used for the realization of TMMs, both for diagnostic and therapeutic applications of ultrasounds, up to today, simulation of acoustic properties was often performed using solid particles, reducing dramatically the transparency and inevitably affecting the homogeneity and the elastic properties of the TMM. By means of concentrated salts solutions and different polysaccharides, an easy method to prepare these TMMs have been developed. This approach would lead to obtain homogenous TMMs with Young modulus ranging over 3 orders of magnitude, i.e. from 2 to 1500 kPa, with independently tunable attenuation properties. An accurate mechanical and acoustic characterization of these TMMs have been performed. Finally, by means of a preliminary trials on protein denaturation induced by a high focused ultrasound transducer in a transparent TMMs with different attenuation values, the mechanism underlying on the formation and propagation of lesion has been investigated. Obtained results suggest that this 'chemical' approach would strongly support in vitro investigations on the open issues related to diagnostic and therapeutic application of ultrasounds.

Independent tuning of acoustic and mechanical properties of phantoms for biomedical applications of ultrasound / Troia, A; Cuccaro, R; Schiavi, A. - In: BIOMEDICAL PHYSICS & ENGINEERING EXPRESS. - ISSN 2057-1976. - 3:2(2017), p. 025011. [10.1088/2057-1976/aa5ed0]

Independent tuning of acoustic and mechanical properties of phantoms for biomedical applications of ultrasound

Troia, A;Cuccaro, R;Schiavi, A
2017

Abstract

In this work the preparation of tissue mimicking materials (TMMs) with independently tunable acoustic and elastic properties is reported. Although a large number of hydrogel, synthetic polymer, polysaccharides or other natural based materials have been proposed and used for the realization of TMMs, both for diagnostic and therapeutic applications of ultrasounds, up to today, simulation of acoustic properties was often performed using solid particles, reducing dramatically the transparency and inevitably affecting the homogeneity and the elastic properties of the TMM. By means of concentrated salts solutions and different polysaccharides, an easy method to prepare these TMMs have been developed. This approach would lead to obtain homogenous TMMs with Young modulus ranging over 3 orders of magnitude, i.e. from 2 to 1500 kPa, with independently tunable attenuation properties. An accurate mechanical and acoustic characterization of these TMMs have been performed. Finally, by means of a preliminary trials on protein denaturation induced by a high focused ultrasound transducer in a transparent TMMs with different attenuation values, the mechanism underlying on the formation and propagation of lesion has been investigated. Obtained results suggest that this 'chemical' approach would strongly support in vitro investigations on the open issues related to diagnostic and therapeutic application of ultrasounds.
File in questo prodotto:
File Dimensione Formato  
Troia_2017_Biomed._Phys._Eng._Express_3_025011.pdf

non disponibili

Tipologia: Versione editoriale
Licenza: Non Pubblico - Accesso privato/ristretto
Dimensione 2.19 MB
Formato Adobe PDF
2.19 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
MANUSCRIPT_ REVISED.pdf

accesso aperto

Tipologia: Documento in Post-print
Licenza: Pubblico - Tutti i diritti riservati
Dimensione 980.65 kB
Formato Adobe PDF
980.65 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11696/57345
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact