Radioactive solutions of 177g,mLuIIICl3 are used for labeling organic compounds for metabolic radiotherapy and radioimmunotherapy. The labeling process involves Lu in III oxidation state, so the presence of other stable impurities in the same oxidation state could result in an isomorphous dilution of radioactive 177gLu. Samples of 177gLuCl3 were analyzed to quantify the chemical impurities with a special regard for trivalent elements with instrumental neutron activation analysis (INAA), carried out in the research nuclear reactor TRIGA MARK II (GA, USA) of the Università degli Studi di Pavia, and electrothermal atomic absorption spectroscopy (ET-AAS) (Varian, USA) at LASA.
Determination of chemical purity and specific activity of (177g,m)LuCl(3) by INAA and ET-AAS / Groppi, F; Persico, E; Quartapelle, E; Gallorini, M; Bergamaschi, Luigi; Cantone, M.. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - 278:3(2008), pp. 595-598. [10.1007/s10967-008-1012-0]
Determination of chemical purity and specific activity of (177g,m)LuCl(3) by INAA and ET-AAS
BERGAMASCHI, LUIGI;
2008
Abstract
Radioactive solutions of 177g,mLuIIICl3 are used for labeling organic compounds for metabolic radiotherapy and radioimmunotherapy. The labeling process involves Lu in III oxidation state, so the presence of other stable impurities in the same oxidation state could result in an isomorphous dilution of radioactive 177gLu. Samples of 177gLuCl3 were analyzed to quantify the chemical impurities with a special regard for trivalent elements with instrumental neutron activation analysis (INAA), carried out in the research nuclear reactor TRIGA MARK II (GA, USA) of the Università degli Studi di Pavia, and electrothermal atomic absorption spectroscopy (ET-AAS) (Varian, USA) at LASA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
